Product Data Sheet
SZM679
Catalog No. A25055
SZM679 is a selective inhibitor of receptor-interacting protein kinase 1 (RIPK1) with a Kd value of 8.6 nM, demonstrating high specificity over RIPK3 (>5000 nM). This compound effectively reverses tumor necrosis factor-induced systemic inflammatory responses and reduces Tau hyperphosphorylation and neuroinflammation in the hippocampus and cortex. SZM679 has significant potential for research applications in Alzheimer's disease and other neurodegenerative disorders.
Chemical Information
| Catalog Num | A25055 |
|---|---|
| M. Wt | 591.51 |
| Formula | C27H18F5N3O5S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3027645-52-6 |
| Synonyms | |
| SMILES | O=C(C1CC(C1)=O)NC2=NC3=CC(F)=C(OC4=CC=C(F)C(NC(CC5=CC=CC(OC(F)(F)F)=C5)=O)=C4)C=C3S2 |
Biological Activity
| Description | SZM679 is a selective inhibitor of receptor-interacting protein kinase 1 (RIPK1) with a Kd value of 8.6 nM, demonstrating high specificity over RIPK3 (>5000 nM). This compound effectively reverses tumor necrosis factor-induced systemic inflammatory responses and reduces Tau hyperphosphorylation and neuroinflammation in the hippocampus and cortex. SZM679 has significant potential for research applications in Alzheimer's disease and other neurodegenerative disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
