Product Data Sheet
Zharp1-211
Catalog No. A25072
Zharp1-211 is a selective inhibitor of RIPK1 kinase, with an EC50 of 53 nM and a Kd of 8.7 nM. This compound effectively reduces IFN-γ-induced STAT1 activation, presenting significant implications for the study of inflammatory responses. Zharp1-211 is suitable for research applications related to graft-versus-host disease and colon cancer, contributing to investigations into therapeutic strategies for these conditions.
Chemical Information
| Catalog Num | A25072 |
|---|---|
| M. Wt | 447.49 |
| Formula | C24H25N5O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2258671-41-7 |
| Synonyms | |
| SMILES | O=C(OC1CCOCC1)N2C3=CC(C(C=C4)=CN5C4=NC(NC(C6CC6)=O)=C5)=CN=C3CC2 |
Biological Activity
| Description | Zharp1-211 is a selective inhibitor of RIPK1 kinase, with an EC50 of 53 nM and a Kd of 8.7 nM. This compound effectively reduces IFN-γ-induced STAT1 activation, presenting significant implications for the study of inflammatory responses. Zharp1-211 is suitable for research applications related to graft-versus-host disease and colon cancer, contributing to investigations into therapeutic strategies for these conditions. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
