Product Data Sheet
Fenbufen-d9
Catalog No. A25091
Fenbufen-d9 is a deuterium-labeled derivative of Fenbufen, a non-steroidal anti-inflammatory drug (NSAID) exhibiting potent antipyretic effects. It targets cyclooxygenase enzymes COX-1 and COX-2, demonstrating inhibitory activities with IC50 values of 3.9 μM and 8.1 μM, respectively. Fenbufen has shown significant efficacy in various preclinical animal models, including carrageenan-induced edema, UV erythema, and adjuvant arthritis. Additionally, it inhibits multiple caspases (caspase-1, 3, 4, 5, 9), making it a valuable tool for research in inflammation and apoptosis.
Chemical Information
| Catalog Num | A25091 |
|---|---|
| M. Wt | 263.34 |
| Formula | C16H5D9O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1189940-96-2 |
| Synonyms | |
| SMILES | C(CCC(O)=O)(=O)C1=C(C(=C(C(=C1[2H])[2H])C2=C(C(=C(C(=C2[2H])[2H])[2H])[2H])[2H])[2H])[2H] |
Biological Activity
| Description | Fenbufen-d9 is a deuterium-labeled derivative of Fenbufen, a non-steroidal anti-inflammatory drug (NSAID) exhibiting potent antipyretic effects. It targets cyclooxygenase enzymes COX-1 and COX-2, demonstrating inhibitory activities with IC50 values of 3.9 μM and 8.1 μM, respectively. Fenbufen has shown significant efficacy in various preclinical animal models, including carrageenan-induced edema, UV erythema, and adjuvant arthritis. Additionally, it inhibits multiple caspases (caspase-1, 3, 4, 5, 9), making it a valuable tool for research in inflammation and apoptosis. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
