Product Data Sheet
Nrf2 activator-21
Catalog No. A25119
Nrf2 activator-21 is a potent activator of the Nrf2 pathway, which disrupts the Keap1-Nrf2 interaction, thereby promoting antioxidant defense mechanisms. This compound exhibits dual antioxidant and neuroprotective properties, significantly reducing apoptosis and caspase-3 activity in hippocampal neurons. Nrf2 activator-21 effectively targets cerebral ischemia/reperfusion injury (CIRI), enhancing neurological function, alleviating anxiety-like behavior, and improving memory in rat models subjected to 2-vessel occlusion (2VO). It serves as a valuable tool for investigating the therapeutic potential of Nrf2 activation in cerebral ischemic conditions.
Chemical Information
| Catalog Num | A25119 |
|---|---|
| M. Wt | 322.31 |
| Formula | C19H14O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1912404-14-8 |
| Synonyms | |
| SMILES | COC1=CC=C2C(OC(C(C(/C=C/C3=CC=C(O)C=C3)=O)=C2)=O)=C1 |
Biological Activity
| Description | Nrf2 activator-21 is a potent activator of the Nrf2 pathway, which disrupts the Keap1-Nrf2 interaction, thereby promoting antioxidant defense mechanisms. This compound exhibits dual antioxidant and neuroprotective properties, significantly reducing apoptosis and caspase-3 activity in hippocampal neurons. Nrf2 activator-21 effectively targets cerebral ischemia/reperfusion injury (CIRI), enhancing neurological function, alleviating anxiety-like behavior, and improving memory in rat models subjected to 2-vessel occlusion (2VO). It serves as a valuable tool for investigating the therapeutic potential of Nrf2 activation in cerebral ischemic conditions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
