Product Data Sheet
Ly101-4B
Catalog No. A25153
Ly101-4B is an apoptosis inducer that primarily targets the regulation of key proteins involved in cell survival and proliferation. It exhibits significant antiproliferative and cytotoxic effects by reducing HSF1 expression and inhibiting microRNA-214 synthesis, leading to the downregulation of HSP27, HSP70, and HSP90. Additionally, Ly101-4B activates caspase 3/7-mediated apoptosis by impairing DNA synthesis and disrupting the cell cycle at the G1/S phase transition, while sparing RNA synthesis and avoiding necrosis. This compound is particularly effective against pancreatic ductal adenocarcinoma cells with distinct genotypes and levels of E2F dependence, making it valuable for research in epithelial ovarian cancer and pancreatic ductal adenocarcinoma.
Chemical Information
| Catalog Num | A25153 |
|---|---|
| M. Wt | 442.51 |
| Formula | C23H30N4O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1415728-94-7 |
| Synonyms | |
| SMILES | O[C@H]1[C@@H](O)[C@H](N2C(C(N)=O)=NC(C#CC3=CC=C(CCCCCCC)C=C3)=N2)O[C@@H]1CO |
Biological Activity
| Description | Ly101-4B is an apoptosis inducer that primarily targets the regulation of key proteins involved in cell survival and proliferation. It exhibits significant antiproliferative and cytotoxic effects by reducing HSF1 expression and inhibiting microRNA-214 synthesis, leading to the downregulation of HSP27, HSP70, and HSP90. Additionally, Ly101-4B activates caspase 3/7-mediated apoptosis by impairing DNA synthesis and disrupting the cell cycle at the G1/S phase transition, while sparing RNA synthesis and avoiding necrosis. This compound is particularly effective against pancreatic ductal adenocarcinoma cells with distinct genotypes and levels of E2F dependence, making it valuable for research in epithelial ovarian cancer and pancreatic ductal adenocarcinoma. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
