Product Data Sheet
KZR-261
Catalog No. A25162
KZR-261 is a selective inhibitor of the Sec61 translocon, which directly binds to the Sec61 channel to impede the biosynthesis of various Sec61 substrate proteins, including oncogenic factors. This compound induces the endoplasmic reticulum stress response and demonstrates broad in vitro anticancer activity. KZR-261 has shown significant antitumor efficacy in murine models and is applicable in the research of multiple myeloma, colorectal cancer, small cell lung cancer, pancreatic cancer, prostate cancer, non-Hodgkin's lymphoma, and mantle cell lymphoma.
Chemical Information
| Catalog Num | A25162 |
|---|---|
| M. Wt | 765.06 |
| Formula | C38H61FN6O5S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2376747-46-3 |
| Synonyms | |
| SMILES | O=S(N1CCCN(CCCN(C[C@H](C1)C)S(N2C[C@H](N([C@@H](C2)C)C3=CC(OC)=CC(F)=C3)C)(=O)=O)CC4CCCCC4)(C5=CC=C(C=C5)N(C)C)=O |
Biological Activity
| Description | KZR-261 is a selective inhibitor of the Sec61 translocon, which directly binds to the Sec61 channel to impede the biosynthesis of various Sec61 substrate proteins, including oncogenic factors. This compound induces the endoplasmic reticulum stress response and demonstrates broad in vitro anticancer activity. KZR-261 has shown significant antitumor efficacy in murine models and is applicable in the research of multiple myeloma, colorectal cancer, small cell lung cancer, pancreatic cancer, prostate cancer, non-Hodgkin's lymphoma, and mantle cell lymphoma. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
