Product Data Sheet
Necrosulfonamide-d4
Catalog No. A25166
Necrosulfonamide-d4 is a deuterium-labeled variant of Necrosulfonamide, a potent inhibitor of MLKL and Gasdermin D (GSDMD). This compound specifically targets the downstream oligomerization step of necroptosis and pyroptosis without affecting upstream signaling pathways. By attenuating the expression of pivotal kinases such as NLRP3 and caspase-1, Necrosulfonamide-d4 modulates inflammatory responses and activates the Nrf2 pathway, enhancing antioxidant enzyme activity. This reagent is valuable for research applications involving neurodegenerative diseases, inflammatory conditions, tissue damage, and programmed necrosis pathways.
Chemical Information
| Catalog Num | A25166 |
|---|---|
| M. Wt | 465.50 |
| Formula | C18H11D4N5O6S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1795144-22-7 |
| Synonyms | |
| SMILES | COC1=NC=CN=C1NS(=O)(C2=C([2H])C([2H])=C(C([2H])=C2[2H])NC(/C=C/C3=CC=C([N+]([O-])=O)S3)=O)=O |
Biological Activity
| Description | Necrosulfonamide-d4 is a deuterium-labeled variant of Necrosulfonamide, a potent inhibitor of MLKL and Gasdermin D (GSDMD). This compound specifically targets the downstream oligomerization step of necroptosis and pyroptosis without affecting upstream signaling pathways. By attenuating the expression of pivotal kinases such as NLRP3 and caspase-1, Necrosulfonamide-d4 modulates inflammatory responses and activates the Nrf2 pathway, enhancing antioxidant enzyme activity. This reagent is valuable for research applications involving neurodegenerative diseases, inflammatory conditions, tissue damage, and programmed necrosis pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
