Product Data Sheet
NEK7 degrader-1
Catalog No. A25175
NEK7 degrader-1 is a potent NEK7 degrader with a DC50 of 0.1 nM, specifically designed to modulate NF-kB signaling pathways. It effectively inhibits caspase-1 activity and reduces IL-1β release in macrophages upon NLRP3 inflammasome activation. This compound is applicable for research in autoinflammatory and autoimmune disorders, including multiple sclerosis, as well as neurodegenerative diseases like Alzheimer's disease, and metabolic disorders such as pericarditis and Type 2 diabetes.
Chemical Information
| Catalog Num | A25175 |
|---|---|
| M. Wt | 449.33 |
| Formula | C21H22Cl2N4O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3069891-91-1 |
| Synonyms | |
| SMILES | O=C1NC(C(CC1)C2=C(C=C(CNC(C(C)(C)C3=NC=C(C)C=N3)=O)C=C2Cl)Cl)=O |
Biological Activity
| Description | NEK7 degrader-1 is a potent NEK7 degrader with a DC50 of 0.1 nM, specifically designed to modulate NF-kB signaling pathways. It effectively inhibits caspase-1 activity and reduces IL-1β release in macrophages upon NLRP3 inflammasome activation. This compound is applicable for research in autoinflammatory and autoimmune disorders, including multiple sclerosis, as well as neurodegenerative diseases like Alzheimer's disease, and metabolic disorders such as pericarditis and Type 2 diabetes. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
