Product Data Sheet
RIPK2-IN-8
Catalog No. A25231
RIPK2-IN-8 is a selective inhibitor of Receptor-interacting protein kinase 2 (RIPK2) with an IC50 of 11 nM. It shows significant selectivity for RIPK2 over RIPK1 (IC50 > 30,000 nM) and a moderate inhibitory effect on RIPK3 (IC50 = 44.61 nM). By inhibiting the NOD2-RIPK2 signaling pathway, RIPK2-IN-8 reduces the expression of key inflammatory cytokines such as IL-6 and TNFα, demonstrating robust anti-inflammatory properties. Its efficacy in an acute liver injury model indicates potential applications in liver injury and inflammation research.
Chemical Information
| Catalog Num | A25231 |
|---|---|
| M. Wt | 453.56 |
| Formula | C22H20FN5OS2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3036254-29-9 |
| Synonyms | |
| SMILES | CCC(NC1CCC(C2=CC(N=CN=C3NC4=CC(N=CS5)=C5C=C4F)=C3S2)=CC1)=O |
Biological Activity
| Description | RIPK2-IN-8 is a selective inhibitor of Receptor-interacting protein kinase 2 (RIPK2) with an IC50 of 11 nM. It shows significant selectivity for RIPK2 over RIPK1 (IC50 > 30,000 nM) and a moderate inhibitory effect on RIPK3 (IC50 = 44.61 nM). By inhibiting the NOD2-RIPK2 signaling pathway, RIPK2-IN-8 reduces the expression of key inflammatory cytokines such as IL-6 and TNFα, demonstrating robust anti-inflammatory properties. Its efficacy in an acute liver injury model indicates potential applications in liver injury and inflammation research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
