Product Data Sheet
10-Hydroxy-2-decenoic acid
Catalog No. A25295
10-Hydroxy-2-decenoic acid (10-HDA) is a bioactive unsaturated medium-chain fatty acid that modulates various physiological processes. It induces reactive oxygen species (ROS)-mediated apoptosis in A549 cells and inhibits VEGF-induced angiogenesis in human venous endothelial cells. Additionally, 10-HDA activates the AMPK-α signaling pathway to alleviate non-alcoholic fatty liver disease (NAFLD) and protects against bone loss by downregulating NF-κB signaling via FFAR4. It also exhibits antimicrobial properties against multiple bacteria and fungi, including Staphylococcus aureus, while demonstrating potential longevity-promoting effects in C. elegans. Furthermore, 10-HDA mitigates osteoarthritis by targeting aspartyl β-hydroxylase to inhibit chondrocyte senescence.
Chemical Information
| Catalog Num | A25295 |
|---|---|
| M. Wt | 186.25 |
| Formula | C10H18O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 765-01-5 |
| Synonyms | 10-HDA; Queen Bee Acid |
| SMILES | O=C(O)/C=C/CCCCCCCO |
Biological Activity
| Description | 10-Hydroxy-2-decenoic acid (10-HDA) is a bioactive unsaturated medium-chain fatty acid that modulates various physiological processes. It induces reactive oxygen species (ROS)-mediated apoptosis in A549 cells and inhibits VEGF-induced angiogenesis in human venous endothelial cells. Additionally, 10-HDA activates the AMPK-α signaling pathway to alleviate non-alcoholic fatty liver disease (NAFLD) and protects against bone loss by downregulating NF-κB signaling via FFAR4. It also exhibits antimicrobial properties against multiple bacteria and fungi, including Staphylococcus aureus, while demonstrating potential longevity-promoting effects in C. elegans. Furthermore, 10-HDA mitigates osteoarthritis by targeting aspartyl β-hydroxylase to inhibit chondrocyte senescence. |
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Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
