Product Data Sheet
Ac-FLTD-CMK
Catalog No. A25299
Ac-FLTD-CMK is a selective inhibitor of inflammatory caspases, specifically targeting caspases-1, -4, -5, and -11, with IC50 values of 46.7 nM, 1.49 μM, and 329 nM, respectively. This compound is derived from gasdermin D (GSDMD) and does not inhibit apoptotic caspases such as caspase-3. Ac-FLTD-CMK is instrumental in research applications focused on inflammatory processes, providing valuable insights into caspase-mediated pathways and their implications in various diseases.
Chemical Information
| Catalog Num | A25299 |
|---|---|
| M. Wt | 569.05 |
| Formula | C26H37ClN4O8 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2376255-48-8 |
| Synonyms | |
| SMILES | ClCC([C@H](CC(O)=O)NC([C@H]([C@H](O)C)NC([C@H](CC(C)C)NC([C@@H](NC(C)=O)CC1=CC=CC=C1)=O)=O)=O)=O |
Biological Activity
| Description | Ac-FLTD-CMK is a selective inhibitor of inflammatory caspases, specifically targeting caspases-1, -4, -5, and -11, with IC50 values of 46.7 nM, 1.49 μM, and 329 nM, respectively. This compound is derived from gasdermin D (GSDMD) and does not inhibit apoptotic caspases such as caspase-3. Ac-FLTD-CMK is instrumental in research applications focused on inflammatory processes, providing valuable insights into caspase-mediated pathways and their implications in various diseases. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
