Product Data Sheet
Simotaxel
Catalog No. A25338
Simotaxel is a microtubule-stabilizing agent that acts as an orally active derivative of the taxane class. It binds to β-tubulin, promoting tubulin polymerization with an EC₅₀ of 0.9 μM, while inhibiting tubulin depolymerization and causing cell cycle arrest in the G₂-M phase. Additionally, Simotaxel disrupts mitotic spindle formation and activates the caspase-dependent apoptotic pathway. This compound is particularly relevant for research into Paclitaxel- and Docetaxel-resistant solid tumors, demonstrating inhibitory effects on cell lines sensitive to these treatments.
Chemical Information
| Catalog Num | A25338 |
|---|---|
| M. Wt | 896.01 |
| Formula | C46H57NO15S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 791635-59-1 |
| Synonyms | MST 997 |
| SMILES | O[C@H]1C[C@]2([H])[C@](CO2)(OC(C)=O)[C@]3([H])[C@@]1(C([C@H](OC(C4CCCC4)=O)C5=C(C)[C@@H](OC([C@H](O)[C@@H](NC(OC(C)C)=O)C6=CC=CS6)=O)C[C@]([C@H]3OC(C7=CC=CC=C7)=O)(O)C5(C)C)=O)C |
Biological Activity
| Description | Simotaxel is a microtubule-stabilizing agent that acts as an orally active derivative of the taxane class. It binds to β-tubulin, promoting tubulin polymerization with an EC₅₀ of 0.9 μM, while inhibiting tubulin depolymerization and causing cell cycle arrest in the G₂-M phase. Additionally, Simotaxel disrupts mitotic spindle formation and activates the caspase-dependent apoptotic pathway. This compound is particularly relevant for research into Paclitaxel- and Docetaxel-resistant solid tumors, demonstrating inhibitory effects on cell lines sensitive to these treatments. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
