Product Data Sheet
NLRP3 modulator 8
Catalog No. A25365
NLRP3 Modulator 8 is a selective modulator targeting the NLRP3 inflammasome, exhibiting a DC50 of 9 nM for NEK7 degradation. It effectively inhibits caspase-1 activity and IL-1β release in macrophages, demonstrating dose-dependent effects upon NLRP3 activation. This compound is valuable for research into autoinflammatory and autoimmune diseases, such as multiple sclerosis and Alzheimer's disease, as well as cardiovascular and metabolic disorders, including pericarditis and Type 2 diabetes.
Chemical Information
| Catalog Num | A25365 |
|---|---|
| M. Wt | 453.29 |
| Formula | C20H19Cl2FN4O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3069891-88-6 |
| Synonyms | |
| SMILES | O=C1NC(C(CC1)C2=C(C=C(CNC(C(C)(C)C3=NC=C(C=N3)F)=O)C=C2Cl)Cl)=O |
Biological Activity
| Description | NLRP3 Modulator 8 is a selective modulator targeting the NLRP3 inflammasome, exhibiting a DC50 of 9 nM for NEK7 degradation. It effectively inhibits caspase-1 activity and IL-1β release in macrophages, demonstrating dose-dependent effects upon NLRP3 activation. This compound is valuable for research into autoinflammatory and autoimmune diseases, such as multiple sclerosis and Alzheimer's disease, as well as cardiovascular and metabolic disorders, including pericarditis and Type 2 diabetes. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
