Product Data Sheet
Hellebrigenin
Catalog No. A25393
Hellebrigenin is an apoptosis inducer that selectively inhibits the MAPK signaling pathway, including ERK, p38, and JNK, as well as XIAP. It plays a critical role in activating intrinsic apoptosis mechanisms, including mitochondrial membrane potential disruption, activation of the Caspase family, PARP cleavage, and modulation of pro- and anti-apoptotic protein levels. Hellebrigenin also induces DNA double-strand breaks, thereby activating the ATM pathway. This compound is primarily utilized in cancer research, particularly in the study of oral squamous cell carcinoma, liver cancer, and other malignancies, due to its capacity to inhibit tumor cell proliferation and clonogenicity.
Chemical Information
| Catalog Num | A25393 |
|---|---|
| M. Wt | 416.51 |
| Formula | C24H32O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 465-90-7 |
| Synonyms | |
| SMILES | O=C[C@@]12[C@]3([H])[C@](CC[C@@]1(C[C@@H](O)CC2)O)([H])[C@@]4([C@@](C)([C@@H](C(C=C5)=COC5=O)CC4)CC3)O |
Biological Activity
| Description | Hellebrigenin is an apoptosis inducer that selectively inhibits the MAPK signaling pathway, including ERK, p38, and JNK, as well as XIAP. It plays a critical role in activating intrinsic apoptosis mechanisms, including mitochondrial membrane potential disruption, activation of the Caspase family, PARP cleavage, and modulation of pro- and anti-apoptotic protein levels. Hellebrigenin also induces DNA double-strand breaks, thereby activating the ATM pathway. This compound is primarily utilized in cancer research, particularly in the study of oral squamous cell carcinoma, liver cancer, and other malignancies, due to its capacity to inhibit tumor cell proliferation and clonogenicity. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
