Product Data Sheet
(E/Z)-Necrosulfonamide
Catalog No. A25395
(E/Z)-Necrosulfonamide is a racemic compound that inhibits MLKL and Gasdermin D (GSDMD), targeting distinct programmed necrosis pathways, specifically necroptosis and pyroptosis. This compound impedes the oligomerization process of downstream executors without interfering with upstream signaling activation. It has been shown to reduce the expression of key kinases such as NLRP3 and caspase-1, activate the Nrf2 pathway, and downregulate various inflammatory factors. Research applications include studies related to neurodegenerative diseases, tissue damage, ischemia-reperfusion injury, inflammatory bowel disease, osteoarthritis, and hair loss.
Chemical Information
| Catalog Num | A25395 |
|---|---|
| M. Wt | 461.47 |
| Formula | C18H15N5O6S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 432531-71-0 |
| Synonyms | |
| SMILES | O=C(/C=C/C1=CC=C(S1)[N+]([O-])=O)NC2=CC=C(C=C2)S(=O)(NC3=NC=CN=C3OC)=O |
Biological Activity
| Description | (E/Z)-Necrosulfonamide is a racemic compound that inhibits MLKL and Gasdermin D (GSDMD), targeting distinct programmed necrosis pathways, specifically necroptosis and pyroptosis. This compound impedes the oligomerization process of downstream executors without interfering with upstream signaling activation. It has been shown to reduce the expression of key kinases such as NLRP3 and caspase-1, activate the Nrf2 pathway, and downregulate various inflammatory factors. Research applications include studies related to neurodegenerative diseases, tissue damage, ischemia-reperfusion injury, inflammatory bowel disease, osteoarthritis, and hair loss. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
