Product Data Sheet
IDN-1965
Catalog No. A25405
IDN-1965 is an irreversible broad-spectrum inhibitor of caspases, crucial proteases involved in apoptosis. By inhibiting caspase activity, IDN-1965 effectively delays cytochrome c release and prevents downstream apoptotic processes, such as DNase activation. In preclinical studies, this compound has demonstrated a significant reduction in cardiomyocyte apoptosis, mitigating left ventricular dilation, systolic dysfunction, and fibrosis in models of dilated cardiomyopathy. IDN-1965 is valuable for research into apoptosis-related conditions, including heart failure and the underlying mechanisms of apoptosis initiation.
Chemical Information
| Catalog Num | A25405 |
|---|---|
| M. Wt | 419.45 |
| Formula | C21H26FN3O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 204919-14-2 |
| Synonyms | |
| SMILES | O=C(CC(C(CF)=O)NC([C@H](C(C)C)NC(C(N1C)=C(C2=C1C=CC=C2)C)=O)=O)O |
Biological Activity
| Description | IDN-1965 is an irreversible broad-spectrum inhibitor of caspases, crucial proteases involved in apoptosis. By inhibiting caspase activity, IDN-1965 effectively delays cytochrome c release and prevents downstream apoptotic processes, such as DNase activation. In preclinical studies, this compound has demonstrated a significant reduction in cardiomyocyte apoptosis, mitigating left ventricular dilation, systolic dysfunction, and fibrosis in models of dilated cardiomyopathy. IDN-1965 is valuable for research into apoptosis-related conditions, including heart failure and the underlying mechanisms of apoptosis initiation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
