Product Data Sheet
Apoptosis inducer 34
Catalog No. A25413
Apoptosis Inducer 34 is a small molecule compound that functions as a caspase activator by directly stimulating the intrinsic apoptotic pathway. It facilitates the oligomerization of Apaf-1 to generate mature apoptosomes, leading to the activation of caspase-9 and caspase-3. This compound effectively enhances the cytochrome c-dependent apoptotic signaling in Jurkat cells, resulting in PARP cleavage and chromosomal DNA fragmentation. Additionally, Apoptosis Inducer 34 demonstrates low toxicity towards normal cells, indicating its potential for selective targeting of cancer cells and making it a valuable tool for researching apoptosis-related cancer mechanisms.
Chemical Information
| Catalog Num | A25413 |
|---|---|
| M. Wt | 336.21 |
| Formula | C17H15Cl2NO2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 582314-48-5 |
| Synonyms | |
| SMILES | O=C(O[C@H]1CCC2=C1C=CC=C2)NCC3=CC=C(Cl)C(Cl)=C3 |
Biological Activity
| Description | Apoptosis Inducer 34 is a small molecule compound that functions as a caspase activator by directly stimulating the intrinsic apoptotic pathway. It facilitates the oligomerization of Apaf-1 to generate mature apoptosomes, leading to the activation of caspase-9 and caspase-3. This compound effectively enhances the cytochrome c-dependent apoptotic signaling in Jurkat cells, resulting in PARP cleavage and chromosomal DNA fragmentation. Additionally, Apoptosis Inducer 34 demonstrates low toxicity towards normal cells, indicating its potential for selective targeting of cancer cells and making it a valuable tool for researching apoptosis-related cancer mechanisms. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
