Product Data Sheet
Isosilybin B
Catalog No. A25438
Isosilybin B is a flavonolignan with significant anticancer activity primarily targeting prostate cancer. Isolated from Silybum marianum, it regulates cell cycle-related proteins by downregulating cyclins D3, D1, A, and E, as well as Cdk4, Cdk2, and Cdc25A. Additionally, Isosilybin B activates Caspases 9 and 3, promoting apoptosis and reducing levels of the androgen receptor (AR) and prostate-specific antigen (PSA). This compound is valuable for research focused on cancer biology and therapeutic interventions.
Chemical Information
| Catalog Num | A25438 |
|---|---|
| M. Wt | 482.44 |
| Formula | C25H22O10 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 142796-22-3 |
| Synonyms | |
| SMILES | O=C1[C@H](O)[C@@H](C2=CC=C(O[C@@H](C3=CC=C(O)C(OC)=C3)[C@H](CO)O4)C4=C2)OC5=CC(O)=CC(O)=C15 |
Biological Activity
| Description | Isosilybin B is a flavonolignan with significant anticancer activity primarily targeting prostate cancer. Isolated from Silybum marianum, it regulates cell cycle-related proteins by downregulating cyclins D3, D1, A, and E, as well as Cdk4, Cdk2, and Cdc25A. Additionally, Isosilybin B activates Caspases 9 and 3, promoting apoptosis and reducing levels of the androgen receptor (AR) and prostate-specific antigen (PSA). This compound is valuable for research focused on cancer biology and therapeutic interventions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
