Product Data Sheet
Tigilanol tiglate
Catalog No. A25474
Tigilanol tiglate is a natural compound that activates protein kinase C (PKC) and C1 domains, leading to mitochondrial and endoplasmic reticulum dysfunction. This dysregulation triggers the unfolded protein response (UPR), resulting in ATP depletion, organelle expansion, and the activation of apoptotic pathways including Caspase activation and gasdermin E cleavage, ultimately driving terminal necrosis. Due to its anti-tumor and immunomodulatory properties, tigilanol tiglate is valuable for research on head and neck squamous cell carcinoma and soft tissue sarcoma.
Chemical Information
| Catalog Num | A25474 |
|---|---|
| M. Wt | 562.65 |
| Formula | C30H42O10 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 943001-56-7 |
| Synonyms | EBC-46 |
| SMILES | CC[C@H](C)C(O[C@@]12[C@@]([C@]3([H])[C@@]4([H])[C@](O4)([C@H]([C@]5([C@](C=C(C5=O)C)([H])[C@]3([C@@H]([C@H]2OC(/C(C)=C/C)=O)C)O)O)O)CO)([H])C1(C)C)=O |
Biological Activity
| Description | Tigilanol tiglate is a natural compound that activates protein kinase C (PKC) and C1 domains, leading to mitochondrial and endoplasmic reticulum dysfunction. This dysregulation triggers the unfolded protein response (UPR), resulting in ATP depletion, organelle expansion, and the activation of apoptotic pathways including Caspase activation and gasdermin E cleavage, ultimately driving terminal necrosis. Due to its anti-tumor and immunomodulatory properties, tigilanol tiglate is valuable for research on head and neck squamous cell carcinoma and soft tissue sarcoma. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
