Product Data Sheet
α5β1 integrin agonist-1
Catalog No. A25488
α5β1 integrin agonist-1 is a potent agonist of the α5β1 integrin, exhibiting an EC50 of 1.5 nM. This compound also inhibits α4β1 integrin activity with an IC50 of 2.99 μM, as demonstrated in Jurkat/VCAM-1 adhesion assays. α5β1 integrin agonist-1 induces concentration-dependent apoptosis and activates the caspase 3/7 pathway in α5β1 integrin-expressing K562 cancer cells. This reagent is suitable for investigations into cancer biology, particularly in studies focusing on integrin-mediated signaling pathways.
Chemical Information
| Catalog Num | A25488 |
|---|---|
| M. Wt | 547.49 |
| Formula | C24H26FN5O9 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2756557-83-0 |
| Synonyms | |
| SMILES | OC(C[C@H]1N(C([C@]1([H])[C@@H](C)OC(CCNC(CN2C(NC(C(F)=C2)=O)=O)=O)=O)=O)C(NC3=C(C=CC=C3)C)=O)=O |
Biological Activity
| Description | α5β1 integrin agonist-1 is a potent agonist of the α5β1 integrin, exhibiting an EC50 of 1.5 nM. This compound also inhibits α4β1 integrin activity with an IC50 of 2.99 μM, as demonstrated in Jurkat/VCAM-1 adhesion assays. α5β1 integrin agonist-1 induces concentration-dependent apoptosis and activates the caspase 3/7 pathway in α5β1 integrin-expressing K562 cancer cells. This reagent is suitable for investigations into cancer biology, particularly in studies focusing on integrin-mediated signaling pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
