Product Data Sheet
ME-344
Catalog No. A25495
ME-344 is an isoflavone that functions as an anti-cancer agent, primarily by inhibiting tubulin polymerization and increasing mitochondrial reactive oxygen species (ROS) generation. This compound effectively induces apoptosis through the activation of caspase-3 and inhibits heme oxygenase-1 (HO-1), affecting its mitochondrial translocation. ME-344 exhibits synergistic effects with Vinblastine in leukemia cells and displays significant anti-tumor activity against leukemia and lung tumors. It is a valuable reagent for research on lung cancer, acute myeloid leukemia, and HER2-negative breast cancer.
Chemical Information
| Catalog Num | A25495 |
|---|---|
| M. Wt | 348.39 |
| Formula | C22H20O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1374524-68-1 |
| Synonyms | |
| SMILES | OC1=CC=C2[C@H](C3=CC=C(O)C=C3)[C@H](C4=CC=C(O)C=C4)COC2=C1C |
Biological Activity
| Description | ME-344 is an isoflavone that functions as an anti-cancer agent, primarily by inhibiting tubulin polymerization and increasing mitochondrial reactive oxygen species (ROS) generation. This compound effectively induces apoptosis through the activation of caspase-3 and inhibits heme oxygenase-1 (HO-1), affecting its mitochondrial translocation. ME-344 exhibits synergistic effects with Vinblastine in leukemia cells and displays significant anti-tumor activity against leukemia and lung tumors. It is a valuable reagent for research on lung cancer, acute myeloid leukemia, and HER2-negative breast cancer. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
