Product Data Sheet
N1,N11-Diethylnorspermine tetrahydrochloride
Catalog No. A25504
N1,N11-Diethylnorspermine tetrahydrochloride is a potent anticancer agent that primarily targets polyamine metabolism. It activates polyamine catabolism and downregulates mTOR signaling pathways, leading to the induction of SSAT and production of hydrogen peroxide. Through the release of cytochrome c from mitochondria, it effectively activates caspase 3, promoting apoptosis in glioblastoma multiforme (GBM) cells. This reagent is valuable for research focused on cancer biology and therapies targeting polyamine synthesis and metabolism.
Chemical Information
| Catalog Num | A25504 |
|---|---|
| M. Wt | 390.26 |
| Formula | C13H36Cl4N4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 156886-85-0 |
| Synonyms | Diethylnorspermine tetrahydrochloride; DENSPM tetrahydrochloride; BENSPM tetrahydrochloride |
| SMILES | CCNCCCNCCCNCCCNCC.[H]Cl.[H]Cl.[H]Cl.[H]Cl |
Biological Activity
| Description | N1,N11-Diethylnorspermine tetrahydrochloride is a potent anticancer agent that primarily targets polyamine metabolism. It activates polyamine catabolism and downregulates mTOR signaling pathways, leading to the induction of SSAT and production of hydrogen peroxide. Through the release of cytochrome c from mitochondria, it effectively activates caspase 3, promoting apoptosis in glioblastoma multiforme (GBM) cells. This reagent is valuable for research focused on cancer biology and therapies targeting polyamine synthesis and metabolism. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
