Product Data Sheet
ST-899
Catalog No. A25523
ST-899 is a specific antagonist of the platelet-activating factor (PAF) receptor, demonstrating significant efficacy in reducing mortality in endotoxin (LPS)-induced shock models in mice. This compound effectively inhibits the elevation of serum tumor necrosis factor (TNF) levels triggered by LPS while showing no impact on interleukin-6 (IL-6) levels. By interrupting the positive feedback loop between PAF and TNF, ST-899 mitigates the inflammatory response. This reagent is valuable for research into inflammatory diseases, particularly septic shock.
Chemical Information
| Catalog Num | A25523 |
|---|---|
| M. Wt | 518.83 |
| Formula | C22H29BrClNO6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 143484-41-7 |
| Synonyms | |
| SMILES | O=C(O/1)C2=CC=C(Cl)C=C2C1=C\COC(C[C@@H](OC(CC(C)C)=O)C[N+](C)(C)C)=O.[Br-] |
Biological Activity
| Description | ST-899 is a specific antagonist of the platelet-activating factor (PAF) receptor, demonstrating significant efficacy in reducing mortality in endotoxin (LPS)-induced shock models in mice. This compound effectively inhibits the elevation of serum tumor necrosis factor (TNF) levels triggered by LPS while showing no impact on interleukin-6 (IL-6) levels. By interrupting the positive feedback loop between PAF and TNF, ST-899 mitigates the inflammatory response. This reagent is valuable for research into inflammatory diseases, particularly septic shock. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
