Product Data Sheet
Apremilast-d3
Catalog No. A25562
Apremilast-d3 is a deuterated form of Apremilast, an orally bioavailable inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC50 of 74 nM. By inhibiting PDE-4, Apremilast-d3 effectively reduces the release of TNF-α in response to lipopolysaccharide (LPS), exhibiting an IC50 of 104 nM. This stable isotope-labeled reagent is valuable for quantitative studies in pharmacokinetics and metabolic research related to inflammatory conditions.
Chemical Information
| Catalog Num | A25562 |
|---|---|
| M. Wt | 463.52 |
| Formula | C22H21D3N2O7S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1258597-46-4 |
| Synonyms | CC-10004-d3 |
| SMILES | CC(NC1=CC=CC(C(N2[C@@H](C3=CC=C(OC([2H])([2H])[2H])C(OCC)=C3)CS(=O)(C)=O)=O)=C1C2=O)=O |
Biological Activity
| Description | Apremilast-d3 is a deuterated form of Apremilast, an orally bioavailable inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC50 of 74 nM. By inhibiting PDE-4, Apremilast-d3 effectively reduces the release of TNF-α in response to lipopolysaccharide (LPS), exhibiting an IC50 of 104 nM. This stable isotope-labeled reagent is valuable for quantitative studies in pharmacokinetics and metabolic research related to inflammatory conditions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
