Product Data Sheet
Apremilast-d8
Catalog No. A25578
Apremilast-d8 is a deuterium-labeled derivative of Apremilast, an orally active inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with a reported IC50 of 74 nM. This reagent effectively inhibits the release of tumor necrosis factor-alpha (TNF-α) induced by lipopolysaccharide (LPS), exhibiting an IC50 of 104 nM. Apremilast-d8 is ideal for stable isotope labeling applications in biochemical and pharmacological research, particularly in studies examining PDE-4 inhibition and its effects on inflammatory pathways.
Chemical Information
| Catalog Num | A25578 |
|---|---|
| M. Wt | 468.55 |
| Formula | C22H16D8N2O7S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1258597-45-3 |
| Synonyms | CC-10004-d8 |
| SMILES | CS(C[C@H](C1=CC(OC([2H])([2H])C([2H])([2H])[2H])=C(C=C1)OC([2H])([2H])[2H])N2C(C3=C(NC(C)=O)C=CC=C3C2=O)=O)(=O)=O |
Biological Activity
| Description | Apremilast-d8 is a deuterium-labeled derivative of Apremilast, an orally active inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with a reported IC50 of 74 nM. This reagent effectively inhibits the release of tumor necrosis factor-alpha (TNF-α) induced by lipopolysaccharide (LPS), exhibiting an IC50 of 104 nM. Apremilast-d8 is ideal for stable isotope labeling applications in biochemical and pharmacological research, particularly in studies examining PDE-4 inhibition and its effects on inflammatory pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
