Product Data Sheet
7,4'-Dimethoxy-3-hydroxyflavone
Catalog No. A25631
7,4'-Dimethoxy-3-hydroxyflavone is a selective antagonist of Protease-Activated Receptor 4 (PAR4). It exhibits potent inhibition of PAR4-mediated human platelet aggregation with an IC50 value of 1.4 μM, effectively disrupting various PAR4 signaling pathways, including NF-κB, Ca2+/protein kinase C, Akt, ERK, and p38. This compound demonstrates potential therapeutic benefits in reducing vascular PAR4 expression and alleviating endothelial dysfunction and oxidative stress in diabetic models. Additionally, 7,4'-Dimethoxy-3-hydroxyflavone has been shown to prevent thrombosis in mice without prolonging bleeding time, suggesting its usefulness in cardiovascular research.
Chemical Information
| Catalog Num | A25631 |
|---|---|
| M. Wt | 298.29 |
| Formula | C17H14O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 13198-99-7 |
| Synonyms | |
| SMILES | COC1=CC=C(C=C1)C2=C(C(C3=CC=C(C=C3O2)OC)=O)O |
Biological Activity
| Description | 7,4'-Dimethoxy-3-hydroxyflavone is a selective antagonist of Protease-Activated Receptor 4 (PAR4). It exhibits potent inhibition of PAR4-mediated human platelet aggregation with an IC50 value of 1.4 μM, effectively disrupting various PAR4 signaling pathways, including NF-κB, Ca2+/protein kinase C, Akt, ERK, and p38. This compound demonstrates potential therapeutic benefits in reducing vascular PAR4 expression and alleviating endothelial dysfunction and oxidative stress in diabetic models. Additionally, 7,4'-Dimethoxy-3-hydroxyflavone has been shown to prevent thrombosis in mice without prolonging bleeding time, suggesting its usefulness in cardiovascular research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
