Product Data Sheet
GTx-134
Catalog No. A25663
GTx-134 is a dual inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR), exhibiting IC50 values of 97 nM and 187 nM, respectively. This compound effectively inhibits IGF-1R autophosphorylation and downstream Akt signaling, thereby interfering with the proliferation and survival of tumor cells. GTx-134 demonstrates broad-spectrum activity against multiple myeloma cell lines, inducing apoptosis in sensitive cells, and significantly reduces tumor growth in mouse models of myeloma. Its potential for synergistic effects with existing therapies makes GTx-134 a valuable reagent for high-risk myeloma research.
Chemical Information
| Catalog Num | A25663 |
|---|---|
| M. Wt | 648.77 |
| Formula | C33H40N6O6S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1008448-19-8 |
| Synonyms | |
| SMILES | CC(C=C(C=C1)C)=C1OC[C@H](O)CNC2=C(C(NC=C2)=O)C3=NC(C=C4C(C(N(C5CCN(CC5)CCS(C)(=O)=O)C4)=O)=C6)=C6N3 |
Biological Activity
| Description | GTx-134 is a dual inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR), exhibiting IC50 values of 97 nM and 187 nM, respectively. This compound effectively inhibits IGF-1R autophosphorylation and downstream Akt signaling, thereby interfering with the proliferation and survival of tumor cells. GTx-134 demonstrates broad-spectrum activity against multiple myeloma cell lines, inducing apoptosis in sensitive cells, and significantly reduces tumor growth in mouse models of myeloma. Its potential for synergistic effects with existing therapies makes GTx-134 a valuable reagent for high-risk myeloma research. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
