Product Data Sheet
A2073
Catalog No. A25728
A2073 is a flavagline derivative that acts as a potent anti-erythroleukemia agent, primarily targeting the inhibition of cell proliferation in erythroleukemia cells. This compound induces cell cycle arrest and suppresses critical signaling pathways, including MAPK, NF-κB, and PI3K. A2073 engages in stable interactions with key cell cycle proteins such as CDK1, CCNA2, and PRIM1, demonstrating significant anti-proliferative efficacy against tumor cells while maintaining a favorable toxicity profile in zebrafish xenograft tumor models. This reagent is suitable for research applications focused on acute erythroleukemia.
Chemical Information
| Catalog Num | A25728 |
|---|---|
| M. Wt | 559.65 |
| Formula | C33H37NO7 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2834742-70-8 |
| Synonyms | |
| SMILES | O=C(CN1CCCCC1)O[C@@H]2C[C@@H](C3=CC=CC=C3)[C@@]4(C5=CC=C(OC)C=C5)[C@]2(O)C6=C(OC)C=C(OC)C=C6O4 |
Biological Activity
| Description | A2073 is a flavagline derivative that acts as a potent anti-erythroleukemia agent, primarily targeting the inhibition of cell proliferation in erythroleukemia cells. This compound induces cell cycle arrest and suppresses critical signaling pathways, including MAPK, NF-κB, and PI3K. A2073 engages in stable interactions with key cell cycle proteins such as CDK1, CCNA2, and PRIM1, demonstrating significant anti-proliferative efficacy against tumor cells while maintaining a favorable toxicity profile in zebrafish xenograft tumor models. This reagent is suitable for research applications focused on acute erythroleukemia. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
