Product Data Sheet
MS143
Catalog No. A25750
MS143 is a potent PROTAC degrader targeting AKT, demonstrating a DC50 of 46 nM and GI50 of 0.8 μM in PC3 cells. This compound effectively induces rapid and robust AKT degradation through the hijacking of the ubiquitin-proteasome system in a concentration- and time-dependent manner. MS143 holds promise in cancer research for its ability to suppress cell growth by promoting targeted protein degradation.
Chemical Information
| Catalog Num | A25750 |
|---|---|
| M. Wt | 1121.87 |
| Formula | C59H81ClN12O6S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2376137-41-4 |
| Synonyms | |
| SMILES | O=C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)[C@H](C(C)(C)C)NC(CCCCCCCCCCC(N(CC4)CCN4CC[C@@H](C5=CC=C(C=C5)Cl)NC(C6(CCN(CC6)C7=C8C(NC=C8)=NC=N7)N)=O)=O)=O |
Biological Activity
| Description | MS143 is a potent PROTAC degrader targeting AKT, demonstrating a DC50 of 46 nM and GI50 of 0.8 μM in PC3 cells. This compound effectively induces rapid and robust AKT degradation through the hijacking of the ubiquitin-proteasome system in a concentration- and time-dependent manner. MS143 holds promise in cancer research for its ability to suppress cell growth by promoting targeted protein degradation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
