Product Data Sheet
MS98
Catalog No. A25760
MS98 is a selective PROTAC degrader targeting AKT, effectively inducing the degradation of total AKT (T-AKT) with a DC50 value of 78 nM. This compound demonstrates high-affinity binding to AKT isoforms, with Kd values of 4 nM, 140 nM, and 8.1 nM for AKT1, AKT2, and AKT3, respectively. MS98 is valuable for research applications in understanding AKT signaling pathways and developing therapeutic strategies for cancer and other diseases associated with dysregulated AKT activity.
Chemical Information
| Catalog Num | A25760 |
|---|---|
| M. Wt | 1097.84 |
| Formula | C58H81ClN10O7S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2376137-31-2 |
| Synonyms | |
| SMILES | C[C@H]1C2=C(N3CCN(CC3)C([C@@H](C4=CC=C(C=C4)Cl)CNCCNC(CCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C)=O)=O)=O)=O)=O)N=CN=C2[C@@H](C1)O |
Biological Activity
| Description | MS98 is a selective PROTAC degrader targeting AKT, effectively inducing the degradation of total AKT (T-AKT) with a DC50 value of 78 nM. This compound demonstrates high-affinity binding to AKT isoforms, with Kd values of 4 nM, 140 nM, and 8.1 nM for AKT1, AKT2, and AKT3, respectively. MS98 is valuable for research applications in understanding AKT signaling pathways and developing therapeutic strategies for cancer and other diseases associated with dysregulated AKT activity. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
