Product Data Sheet
Degalactotigonin
Catalog No. A25776
Degalactotigonin is a saponin-selective inhibitor that targets key pathways, including EGFR, GSK3β, and Hedgehog/Gli1. It effectively inhibits EGFR phosphorylation and the downstream Akt/ERK signaling pathway, while also disrupting the Hedgehog/Gli1 pathway through the inactivation of GSK3β. These actions result in the induction of apoptosis in cancer cells, cell cycle arrest, and inhibition of cell migration and invasion. Degalactotigonin is suitable for research focused on malignant tumors, particularly pancreatic cancer and osteosarcoma.
Chemical Information
| Catalog Num | A25776 |
|---|---|
| M. Wt | 1035.17 |
| Formula | C50H82O22 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 39941-51-0 |
| Synonyms | |
| SMILES | C[C@@]12[C@]3([H])[C@](O[C@]4(CC[C@H](CO4)C)[C@H]3C)([H])C[C@@]1([H])[C@@]5([H])[C@]([C@@]6([C@@](C[C@H](CC6)O[C@]7([H])O[C@@H]([C@@H]([C@@H]([C@H]7O)O)O[C@@]8([H])[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O[C@@]9([H])[C@@H]([C@H]([C@@H](CO9)O)O)O)O[C@]%10([H])O[C@@H]([C@H]([C@@H]([C@H]%10O)O)O)CO)CO)([H])CC5)C)([H])CC2 |
Biological Activity
| Description | Degalactotigonin is a saponin-selective inhibitor that targets key pathways, including EGFR, GSK3β, and Hedgehog/Gli1. It effectively inhibits EGFR phosphorylation and the downstream Akt/ERK signaling pathway, while also disrupting the Hedgehog/Gli1 pathway through the inactivation of GSK3β. These actions result in the induction of apoptosis in cancer cells, cell cycle arrest, and inhibition of cell migration and invasion. Degalactotigonin is suitable for research focused on malignant tumors, particularly pancreatic cancer and osteosarcoma. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
