Product Data Sheet
KIM-161
Catalog No. A25813
KIM-161 is a selective inhibitor of the PIK3CA pathway, demonstrating potent antiproliferative effects with IC50 values of 1.428 µM and 1.562 µM against PI3KCA mutant breast cancer cell lines MCF7 and T47D, respectively. This compound induces apoptosis and cell cycle arrest through the inhibition of the PI3K/AKT/mTOR signaling cascade while also promoting reactive oxygen species (ROS) production. KIM-161 is a valuable tool for investigating breast cancer, particularly in the context of PIK3CA mutations and their therapeutic implications.
Chemical Information
| Catalog Num | A25813 |
|---|---|
| M. Wt | 439.51 |
| Formula | C27H25N3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2559686-28-9 |
| Synonyms | |
| SMILES | O=C(NCC1=CC=CC=C1)CC2=CC=C(N3C(/C(N=C3C)=C/C4=CC=C(OC)C=C4)=O)C=C2 |
Biological Activity
| Description | KIM-161 is a selective inhibitor of the PIK3CA pathway, demonstrating potent antiproliferative effects with IC50 values of 1.428 µM and 1.562 µM against PI3KCA mutant breast cancer cell lines MCF7 and T47D, respectively. This compound induces apoptosis and cell cycle arrest through the inhibition of the PI3K/AKT/mTOR signaling cascade while also promoting reactive oxygen species (ROS) production. KIM-161 is a valuable tool for investigating breast cancer, particularly in the context of PIK3CA mutations and their therapeutic implications. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
