Product Data Sheet
CIB-L43
Catalog No. A25853
CIB-L43 is an orally active inhibitor of TAR RNA binding protein (TRBP), demonstrating a dissociation constant (KD) of 4.78 nM. This compound disrupts TRBP-Dicer interactions, with an inhibitory concentration (IC50) of 2.34 μM. By suppressing the biosynthesis of oncogenic miR-21, CIB-L43 promotes increased expression of PTEN and Smad7, ultimately inhibiting AKT and TGF-β signaling pathways. These properties make it a valuable tool for studying hepatocellular carcinoma (HCC) cell proliferation and migration.
Chemical Information
| Catalog Num | A25853 |
|---|---|
| M. Wt | 304.36 |
| Formula | C15H16N2O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1082942-70-8 |
| Synonyms | |
| SMILES | OC(C1=C(N=C(C2=CC=C(C=C2)N3CCOCC3)S1)C)=O |
Biological Activity
| Description | CIB-L43 is an orally active inhibitor of TAR RNA binding protein (TRBP), demonstrating a dissociation constant (KD) of 4.78 nM. This compound disrupts TRBP-Dicer interactions, with an inhibitory concentration (IC50) of 2.34 μM. By suppressing the biosynthesis of oncogenic miR-21, CIB-L43 promotes increased expression of PTEN and Smad7, ultimately inhibiting AKT and TGF-β signaling pathways. These properties make it a valuable tool for studying hepatocellular carcinoma (HCC) cell proliferation and migration. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
