Product Data Sheet
Tetrahydroalstonine
Catalog No. A25875
Tetrahydroalstonine is an indole alkaloid that acts as a selective antagonist of the α₂-adrenergic receptor. This compound demonstrates neuroprotective effects and has been shown to modulate autophagy-lysosomal function through the activation of the Akt/mTOR signaling pathway. Additionally, Tetrahydroalstonine significantly mitigates injury to primary cortical neurons induced by oxygen-glucose deprivation/reperfusion, making it a valuable tool for research into neuroprotection and cellular stress responses.
Chemical Information
| Catalog Num | A25875 |
|---|---|
| M. Wt | 352.43 |
| Formula | C21H24N2O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 6474-90-4 |
| Synonyms | (-)-Tetrahydroalstonine |
| SMILES | O=C(OC)C1=CO[C@@H](C)[C@@]2([H])[C@]1([H])C[C@@]3([H])C4=C(C5=CC=CC=C5N4)CCN3C2 |
Biological Activity
| Description | Tetrahydroalstonine is an indole alkaloid that acts as a selective antagonist of the α₂-adrenergic receptor. This compound demonstrates neuroprotective effects and has been shown to modulate autophagy-lysosomal function through the activation of the Akt/mTOR signaling pathway. Additionally, Tetrahydroalstonine significantly mitigates injury to primary cortical neurons induced by oxygen-glucose deprivation/reperfusion, making it a valuable tool for research into neuroprotection and cellular stress responses. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
