Product Data Sheet
Demethylasterriquinone B1
Catalog No. A25947
Demethylasterriquinone B1 is an orally active insulin receptor agonist that functions as an AKT activator. This compound enhances eNOS expression and activity, resulting in increased nitric oxide production, while simultaneously downregulating the NADPH oxidase subunit p22phox to mitigate oxidative stress and improve vascular endothelial function. Additionally, Demethylasterriquinone B1, when combined with an AKT inhibitor, can modulate the insulin signaling pathway to activate antiviral pathways, including RNA interference and JAK/STAT, in mosquitoes, thereby demonstrating potential in reducing Zika virus infection.
Chemical Information
| Catalog Num | A25947 |
|---|---|
| M. Wt | 506.59 |
| Formula | C32H30N2O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 78860-34-1 |
| Synonyms | DAQ B1; L-783281; Dimethylasterriquinone |
| SMILES | C=CC(C)(C1=C(C(C(C(O)=C2C3=CNC4=C3C=CC=C4C/C=C(C)/C)=O)=C(O)C2=O)C5=C(C=CC=C5)N1)C |
Biological Activity
| Description | Demethylasterriquinone B1 is an orally active insulin receptor agonist that functions as an AKT activator. This compound enhances eNOS expression and activity, resulting in increased nitric oxide production, while simultaneously downregulating the NADPH oxidase subunit p22phox to mitigate oxidative stress and improve vascular endothelial function. Additionally, Demethylasterriquinone B1, when combined with an AKT inhibitor, can modulate the insulin signaling pathway to activate antiviral pathways, including RNA interference and JAK/STAT, in mosquitoes, thereby demonstrating potential in reducing Zika virus infection. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
