Product Data Sheet
4,4'-Sulfonyldiphenol
Catalog No. A25971
4,4'-Sulfonyldiphenol, an estrogen receptor agonist, is a significant chemical interest due to its role as a substitute for Bisphenol A in various industrial and consumer applications. This compound exhibits competitive binding to thyroid hormone receptors with IC50 values of 2650 μM for TRα and 2294 μM for TRβ, influencing breast development and androgen receptor downregulation in fetal testes. Additionally, 4,4'-Sulfonyldiphenol promotes glioblastoma progression by activating the EZH2-mediated PI3K/AKT/mTOR pathway. Chronic exposure can lead to lipid accumulation and metabolic alterations, including dyslipidemia and obesity, while also inducing intestinal inflammation through microbiome disruption and accelerating atherosclerosis in zebrafish models.
Chemical Information
| Catalog Num | A25971 |
|---|---|
| M. Wt | 250.28 |
| Formula | C12H10O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 80-09-1 |
| Synonyms | Bisphenol S; Bis(4-hydroxyphenyl) sulfone |
| SMILES | O=S(C1=CC=C(O)C=C1)(C2=CC=C(O)C=C2)=O |
Biological Activity
| Description | 4,4'-Sulfonyldiphenol, an estrogen receptor agonist, is a significant chemical interest due to its role as a substitute for Bisphenol A in various industrial and consumer applications. This compound exhibits competitive binding to thyroid hormone receptors with IC50 values of 2650 μM for TRα and 2294 μM for TRβ, influencing breast development and androgen receptor downregulation in fetal testes. Additionally, 4,4'-Sulfonyldiphenol promotes glioblastoma progression by activating the EZH2-mediated PI3K/AKT/mTOR pathway. Chronic exposure can lead to lipid accumulation and metabolic alterations, including dyslipidemia and obesity, while also inducing intestinal inflammation through microbiome disruption and accelerating atherosclerosis in zebrafish models. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
