Product Data Sheet
Osthenol
Catalog No. A26001
Osthenol is a reversible and selective competitive inhibitor of human monoamine oxidase A (hMAO-A), with an IC50 of 0.74 μM and a Ki of 0.26 μM. This compound exhibits both antifungal and antibacterial properties, while also modulating the oxidative deamination of monoamine neurotransmitters. Additionally, Osthenol has been shown to inhibit the PI3K/AKT signaling pathway, leading to apoptosis in colon cancer cells, G1 phase cell cycle arrest, and reduced cell proliferation. Its applications are significant in the study of neurological disorders and cancer, particularly in targeting MAO-A for depression and investigating mechanisms in colon cancer.
Chemical Information
| Catalog Num | A26001 |
|---|---|
| M. Wt | 230.26 |
| Formula | C14H14O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 484-14-0 |
| Synonyms | Ostenol |
| SMILES | O=C1C=CC2=CC=C(O)C(C/C=C(C)\C)=C2O1 |
Biological Activity
| Description | Osthenol is a reversible and selective competitive inhibitor of human monoamine oxidase A (hMAO-A), with an IC50 of 0.74 μM and a Ki of 0.26 μM. This compound exhibits both antifungal and antibacterial properties, while also modulating the oxidative deamination of monoamine neurotransmitters. Additionally, Osthenol has been shown to inhibit the PI3K/AKT signaling pathway, leading to apoptosis in colon cancer cells, G1 phase cell cycle arrest, and reduced cell proliferation. Its applications are significant in the study of neurological disorders and cancer, particularly in targeting MAO-A for depression and investigating mechanisms in colon cancer. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
