Product Data Sheet
MN-25
Catalog No. A26066
MN-25 is an orally active indolpyridone that functions as a selective CB2 agonist, exhibiting a Ki of 245 nM for CB1 and a potent 11 nM for CB2. This compound demonstrates significant anti-inflammatory properties by inhibiting TNF-R release in human peripheral blood mononuclear cells in vitro, with an IC50 of 33 μM. In vivo studies have shown that MN-25 is effective in reducing acute inflammation in a mouse model at oral doses up to 50 mg/kg, making it a valuable reagent for exploring cannabinoid receptor biology and therapeutic applications in inflammation.
Chemical Information
| Catalog Num | A26066 |
|---|---|
| M. Wt | 439.59 |
| Formula | C26H37N3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 501926-82-5 |
| Synonyms | |
| SMILES | C[C@]1(C[C@](CC1)([H])C2(C)C)[C@@H]2NC(C3=CN(C4=C(OC)C=CC=C43)CCN5CCOCC5)=O |
Biological Activity
| Description | MN-25 is an orally active indolpyridone that functions as a selective CB2 agonist, exhibiting a Ki of 245 nM for CB1 and a potent 11 nM for CB2. This compound demonstrates significant anti-inflammatory properties by inhibiting TNF-R release in human peripheral blood mononuclear cells in vitro, with an IC50 of 33 μM. In vivo studies have shown that MN-25 is effective in reducing acute inflammation in a mouse model at oral doses up to 50 mg/kg, making it a valuable reagent for exploring cannabinoid receptor biology and therapeutic applications in inflammation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
