Product Data Sheet

BMS-751324

Catalog No. A26076

main product photo
BMS-751324 is a selective inhibitor of p38α MAPK, a key regulator in the inflammatory response pathway. This compound demonstrates significant anti-inflammatory effects, as evidenced by its ability to reduce foot swelling and inhibit LPS-induced TNFα production in an arthritic rat model. BMS-751324 is suitable for research applications focused on inflammation, arthritis, and related pathways.
Chemical Information
Catalog NumA26076
M. Wt694.63
FormulaC32H35N6O10P
Purity>98%
Storageat -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
CAS No.948842-66-8
Synonyms
SMILESCC1=CC=C(C(NC2CC2)=O)C=C1NC3=NC=NN4C3=C(C)C(C(N(C(OCOC(CC5=CC=C(OP(O)(O)=O)C=C5)=O)=O)CCC)=O)=C4
Biological Activity
DescriptionBMS-751324 is a selective inhibitor of p38α MAPK, a key regulator in the inflammatory response pathway. This compound demonstrates significant anti-inflammatory effects, as evidenced by its ability to reduce foot swelling and inhibit LPS-induced TNFα production in an arthritic rat model. BMS-751324 is suitable for research applications focused on inflammation, arthritis, and related pathways.
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