Product Data Sheet
Cnidilide
Catalog No. A26080
Cnidilide is a natural product of alkylphthalein that primarily targets the inhibition of pro-inflammatory pathways. It significantly reduces the production of nitric oxide (NO) and prostaglandin E2 (PGE2) by downregulating the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in response to lipopolysaccharide (LPS) stimulation. Additionally, Cnidilide suppresses the production of pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α. This compound specifically inhibits the phosphorylation of p38 MAPK and JNK, thereby blocking the signaling pathways mediated by AP-1 and NF-κB, making it a valuable tool for researching inflammation-related conditions.
Chemical Information
| Catalog Num | A26080 |
|---|---|
| M. Wt | 194.27 |
| Formula | C12H18O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3674-03-1 |
| Synonyms | |
| SMILES | CCCC[C@H]1[C@]2([H])[C@](C=CCC2)([H])C(O1)=O |
Biological Activity
| Description | Cnidilide is a natural product of alkylphthalein that primarily targets the inhibition of pro-inflammatory pathways. It significantly reduces the production of nitric oxide (NO) and prostaglandin E2 (PGE2) by downregulating the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in response to lipopolysaccharide (LPS) stimulation. Additionally, Cnidilide suppresses the production of pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α. This compound specifically inhibits the phosphorylation of p38 MAPK and JNK, thereby blocking the signaling pathways mediated by AP-1 and NF-κB, making it a valuable tool for researching inflammation-related conditions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
