Product Data Sheet

Revamilast

Catalog No. A26113

main product photo
Revamilast is an orally active phosphodiesterase-4 (PDE4) inhibitor with a reported IC50 of 3 nM. This compound effectively inhibits the production of tumor necrosis factor-alpha (TNF-α), making it a valuable tool for research into inflammatory conditions. Applications include studies related to rheumatoid arthritis, plaque psoriasis, asthma, and other related inflammatory diseases.
Chemical Information
Catalog NumA26113
M. Wt440.18
FormulaC18H9Cl2F2N3O4
Purity>98%
Storageat -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
CAS No.893555-90-3
SynonymsGRC 4039
SMILESO=C(C1=C(C2=C3C=CN=C2)C(O3)=C(OC(F)F)C=C1)NC4=C(Cl)C=[N+]([O-])C=C4Cl
Biological Activity
DescriptionRevamilast is an orally active phosphodiesterase-4 (PDE4) inhibitor with a reported IC50 of 3 nM. This compound effectively inhibits the production of tumor necrosis factor-alpha (TNF-α), making it a valuable tool for research into inflammatory conditions. Applications include studies related to rheumatoid arthritis, plaque psoriasis, asthma, and other related inflammatory diseases.
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