Product Data Sheet
HSP90-IN-31
Catalog No. A26119
HSP90-IN-31 is an anti-inflammatory agent that targets heat shock protein 90 (HSP90). It effectively reduces the expression of costimulatory molecules CD80 and CD86 on dendritic cells, leading to decreased production of pro-inflammatory cytokines, including IL-6, TNF-α, and IL-1β, in bone marrow-derived dendritic cells and peritoneal macrophages upon LPS stimulation. In a delayed-type hypersensitivity mouse model, HSP90-IN-31 significantly diminishes ear swelling and lowers pro-inflammatory cytokine levels in the spleen, making it a valuable tool for studying inflammatory processes and potential therapeutic applications.
Chemical Information
| Catalog Num | A26119 |
|---|---|
| M. Wt | 384.47 |
| Formula | C22H28N2O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2117645-10-8 |
| Synonyms | |
| SMILES | CC(C)C1=C(O)C=C(O)C(C(N(C)CC2=CC=C(C(NCCC)=O)C=C2)=O)=C1 |
Biological Activity
| Description | HSP90-IN-31 is an anti-inflammatory agent that targets heat shock protein 90 (HSP90). It effectively reduces the expression of costimulatory molecules CD80 and CD86 on dendritic cells, leading to decreased production of pro-inflammatory cytokines, including IL-6, TNF-α, and IL-1β, in bone marrow-derived dendritic cells and peritoneal macrophages upon LPS stimulation. In a delayed-type hypersensitivity mouse model, HSP90-IN-31 significantly diminishes ear swelling and lowers pro-inflammatory cytokine levels in the spleen, making it a valuable tool for studying inflammatory processes and potential therapeutic applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
