Product Data Sheet
GE1111
Catalog No. A26150
GE1111 is an antagonist of the MRGPRX2 receptor, with an IC50 value of 9.4 μM. This compound effectively inhibits MRGPRX2/MRGPRB2-mediated mast cell activation, leading to the reduction of pro-inflammatory cytokines, including TSLP, IL-13, MCP-1, TNF-α, and IL-1β. Additionally, GE1111 preserves claudin 1 and involucrin expression, enhances macrophage phagocytic activity, and modulates STIM1 and phosphorylated AKT activation. Its anti-inflammatory and anti-allergic properties make GE1111 relevant for research in conditions such as rosacea, atopic dermatitis, and ulcerative colitis.
Chemical Information
| Catalog Num | A26150 |
|---|---|
| M. Wt | 466.48 |
| Formula | C28H22N2O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2883669-12-1 |
| Synonyms | |
| SMILES | O=CC1=CC2=C3C(C1C)=C(O)C=CC3=CC(C4=CC5=C(C=C4C(OC)=O)C=C(NC(N)=O)C=C5)=C2 |
Biological Activity
| Description | GE1111 is an antagonist of the MRGPRX2 receptor, with an IC50 value of 9.4 μM. This compound effectively inhibits MRGPRX2/MRGPRB2-mediated mast cell activation, leading to the reduction of pro-inflammatory cytokines, including TSLP, IL-13, MCP-1, TNF-α, and IL-1β. Additionally, GE1111 preserves claudin 1 and involucrin expression, enhances macrophage phagocytic activity, and modulates STIM1 and phosphorylated AKT activation. Its anti-inflammatory and anti-allergic properties make GE1111 relevant for research in conditions such as rosacea, atopic dermatitis, and ulcerative colitis. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
