Product Data Sheet
RP-832c
Catalog No. A26153
RP-832c is a synthetic analogue of host defense peptides that selectively targets the mannose receptor CD206 on M2 polarized macrophages (Kd = 3.5 μM). Binding of RP-832c to CD206 induces significant conformational changes, activating signaling pathways that promote apoptosis and repolarization of M2 macrophages to an M1 phenotype. The treatment with RP-832c effectively reduces CD206 gene expression while transiently increasing TNF-α levels, a hallmark of M1 macrophages. This reagent is valuable for research on T-cell lymphoma (CTCL) and idiopathic pulmonary fibrosis (IPF).
Chemical Information
| Catalog Num | A26153 |
|---|---|
| M. Wt | 1367.60 |
| Formula | C68H94N20O11 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2375823-45-1 |
| Synonyms | |
| SMILES | C([C@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC(CNC(CNC([C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@H](CC=3C=4C(NC3)=CC=CC4)NC([C@H](CCCNC(=N)N)N)=O)=O)CCCCN)=O)=O)=O)=O)=O)CCCCN)=O)C(N[C@@H](CCCNC(=N)N)C(O)=O)=O)C=5C=6C(NC5)=CC=CC6 |
Biological Activity
| Description | RP-832c is a synthetic analogue of host defense peptides that selectively targets the mannose receptor CD206 on M2 polarized macrophages (Kd = 3.5 μM). Binding of RP-832c to CD206 induces significant conformational changes, activating signaling pathways that promote apoptosis and repolarization of M2 macrophages to an M1 phenotype. The treatment with RP-832c effectively reduces CD206 gene expression while transiently increasing TNF-α levels, a hallmark of M1 macrophages. This reagent is valuable for research on T-cell lymphoma (CTCL) and idiopathic pulmonary fibrosis (IPF). |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
