Product Data Sheet
L524-0366
Catalog No. A26194
L524-0366 is a specific TWEAK-Fn14 inhibitor that competitively binds to the Fn14 receptor with a dissociation constant (KD) of 7.12 μM, effectively blocking TWEAK's interaction with Fn14. This compound demonstrates a significant inhibition rate of 16% in TWEAK-Fn14 binding and has been shown to inhibit TWEAK-induced glioma cell migration while displaying minimal cytotoxicity. L524-0366 serves as a valuable tool for research in cancer biology and therapeutic strategies targeting glioma progression.
Chemical Information
| Catalog Num | A26194 |
|---|---|
| M. Wt | 308.79 |
| Formula | C13H13ClN4OS |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 951612-19-4 |
| Synonyms | |
| SMILES | O=C(N1CCSCC1)C2=CN(N=N2)C3=CC=CC(Cl)=C3 |
Biological Activity
| Description | L524-0366 is a specific TWEAK-Fn14 inhibitor that competitively binds to the Fn14 receptor with a dissociation constant (KD) of 7.12 μM, effectively blocking TWEAK's interaction with Fn14. This compound demonstrates a significant inhibition rate of 16% in TWEAK-Fn14 binding and has been shown to inhibit TWEAK-induced glioma cell migration while displaying minimal cytotoxicity. L524-0366 serves as a valuable tool for research in cancer biology and therapeutic strategies targeting glioma progression. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
