Product Data Sheet
IW927
Catalog No. A26209
IW927 is a photochemically enhanced inhibitor that targets the TNF-α-TNFR1 interaction, effectively blocking the binding of TNF-α to TNFR1 with an IC50 of 50 nM. It exhibits weak reversible binding affinity (Kd = 40-100 μM) and covalently modifies TNFR1 through a photochemical reaction, without affecting TNFR2 or CD40. IW927 also inhibits TNF-α induced IκB phosphorylation with an IC50 of 600 nM, making it a valuable tool for studying TNF-α signaling pathways and the development of light-independent inhibitors.
Chemical Information
| Catalog Num | A26209 |
|---|---|
| M. Wt | 441.57 |
| Formula | C22H23N3O3S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 389142-48-7 |
| Synonyms | |
| SMILES | O=C(C1=CC2=C(C=C(S2)C3=CC=CC(OC)=C3)N1C4=S)N4CCCN5CCOCC5 |
Biological Activity
| Description | IW927 is a photochemically enhanced inhibitor that targets the TNF-α-TNFR1 interaction, effectively blocking the binding of TNF-α to TNFR1 with an IC50 of 50 nM. It exhibits weak reversible binding affinity (Kd = 40-100 μM) and covalently modifies TNFR1 through a photochemical reaction, without affecting TNFR2 or CD40. IW927 also inhibits TNF-α induced IκB phosphorylation with an IC50 of 600 nM, making it a valuable tool for studying TNF-α signaling pathways and the development of light-independent inhibitors. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
