Product Data Sheet
Amcinonide
Catalog No. A26243
Amcinonide is a glucocorticoid receptor agonist that exhibits anti-inflammatory properties by inhibiting nitric oxide (NO) release with an IC50 of 3.38 nM. It effectively downregulates the expression of pro-inflammatory genes such as iNOS, TNF-α, and IL-1β in glial cells. Moreover, Amcinonide alters T cell populations by reducing T6+/Ia+ cells while increasing T6+/Ia- cells, leading to a selective decrease in Ia antigen expression. This compound is applicable in research related to eczematous dermatitis and the modulation of inflammatory responses.
Chemical Information
| Catalog Num | A26243 |
|---|---|
| M. Wt | 502.57 |
| Formula | C28H35FO7 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 51022-69-6 |
| Synonyms | CL-34699 |
| SMILES | C[C@@]12[C@@]3(C(COC(C)=O)=O)[C@@](OC4(O3)CCCC4)([H])C[C@@]1([H])[C@]5([H])CCC6=CC(C=C[C@]6(C)[C@@]5(F)[C@@H](O)C2)=O |
Biological Activity
| Description | Amcinonide is a glucocorticoid receptor agonist that exhibits anti-inflammatory properties by inhibiting nitric oxide (NO) release with an IC50 of 3.38 nM. It effectively downregulates the expression of pro-inflammatory genes such as iNOS, TNF-α, and IL-1β in glial cells. Moreover, Amcinonide alters T cell populations by reducing T6+/Ia+ cells while increasing T6+/Ia- cells, leading to a selective decrease in Ia antigen expression. This compound is applicable in research related to eczematous dermatitis and the modulation of inflammatory responses. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
