Product Data Sheet
JNJ525
Catalog No. A26249
JNJ525 is a selective TNFα inhibitor that shows IC50 values of 1.2 μM and 1.1 μM against TNFR1 and TNFR2, respectively. It effectively disrupts the protein-protein interaction between TNFα and its receptors by forming ordered aggregates and inducing structural transitions of the TNFα protein. JNJ525's inhibitory activity may be compromised in the presence of 0.1% Triton X-100, highlighting its specificity for TNFα interactions. This compound is valuable for studies involving inflammation and autoimmune disorders.
Chemical Information
| Catalog Num | A26249 |
|---|---|
| M. Wt | 514.62 |
| Formula | C31H30N8 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2092913-64-7 |
| Synonyms | |
| SMILES | NC1=NC=CC(N(CC2=CC=CC=C2)C3=C(C4=CC(C5=CN=C(N6CCNCC6)N=C5)=CC=C4)C=CC=C3)=N1 |
Biological Activity
| Description | JNJ525 is a selective TNFα inhibitor that shows IC50 values of 1.2 μM and 1.1 μM against TNFR1 and TNFR2, respectively. It effectively disrupts the protein-protein interaction between TNFα and its receptors by forming ordered aggregates and inducing structural transitions of the TNFα protein. JNJ525's inhibitory activity may be compromised in the presence of 0.1% Triton X-100, highlighting its specificity for TNFα interactions. This compound is valuable for studies involving inflammation and autoimmune disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
