Product Data Sheet
Tris(2-chloroethyl) phosphate
Catalog No. A26258
Tris(2-chloroethyl) phosphate (TCEP) is an organic phosphorus compound that functions primarily as a flame-retardant plasticizer. It exhibits hepatotoxic effects characterized by an increase in reactive oxygen species (ROS) and calcium ion influx, leading to mitochondrial membrane potential disruption, DNA damage, and programmed cell death. TCEP has been shown to directly interact with the farnesoid X receptor (FXR), promoting obesity and fatty liver development in murine models. Additionally, TCEP activates the TLR4/NF-κB signaling pathway, contributing to liver inflammation, making it relevant for studies on metabolic disorders and toxicology.
Chemical Information
| Catalog Num | A26258 |
|---|---|
| M. Wt | 285.49 |
| Formula | C6H12Cl3O4P |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 115-96-8 |
| Synonyms | TCEP |
| SMILES | O=P(OCCCl)(OCCCl)OCCCl |
Biological Activity
| Description | Tris(2-chloroethyl) phosphate (TCEP) is an organic phosphorus compound that functions primarily as a flame-retardant plasticizer. It exhibits hepatotoxic effects characterized by an increase in reactive oxygen species (ROS) and calcium ion influx, leading to mitochondrial membrane potential disruption, DNA damage, and programmed cell death. TCEP has been shown to directly interact with the farnesoid X receptor (FXR), promoting obesity and fatty liver development in murine models. Additionally, TCEP activates the TLR4/NF-κB signaling pathway, contributing to liver inflammation, making it relevant for studies on metabolic disorders and toxicology. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
