Product Data Sheet
Pyrrothiogatain
Catalog No. A26261
Pyrrothiogatain is a selective inhibitor of the transcription factor GATA3, exhibiting an IC50 of 54.7 μM. By disrupting the DNA-binding activity of GATA3, Pyrrothiogatain effectively impedes Th2 cell differentiation and the production of Th2 cytokines. Additionally, it demonstrates anti-infective properties by inhibiting ACE2 expression. This compound is relevant for research in inflammation, immunology, infectious diseases, and cancer, including studies on colon cancer and SARS-CoV-2 infection.
Chemical Information
| Catalog Num | A26261 |
|---|---|
| M. Wt | 221.28 |
| Formula | C11H11NO2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 477888-48-5 |
| Synonyms | |
| SMILES | O=C(C1=C(N2C(C)=CC=C2C)C=CS1)O |
Biological Activity
| Description | Pyrrothiogatain is a selective inhibitor of the transcription factor GATA3, exhibiting an IC50 of 54.7 μM. By disrupting the DNA-binding activity of GATA3, Pyrrothiogatain effectively impedes Th2 cell differentiation and the production of Th2 cytokines. Additionally, it demonstrates anti-infective properties by inhibiting ACE2 expression. This compound is relevant for research in inflammation, immunology, infectious diseases, and cancer, including studies on colon cancer and SARS-CoV-2 infection. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
